Biochemical parameters of blood and tissue of the gastrocnemius muscle in chronically alcoholized rats under oral administration of C(60) fullerene aqueous solution

Biochemical indices of blood and tissue the gastrocnemius muscle chronically alcoholized (for 3, 6 9 months) rats were studied. С60 fullerene aqueous solution (C60FAS) was administered orally as a pharmacological agent at dose 1 mg/kg daily throughout experiment in three routes: h before alcohol intake (preventive regimen), together with (therapeutic regimen I) after II). Creatine phosphokinase (CPK), lactate dehydrogenase (LDH), catalase, superoxide dismutase, glutathione peroxidase (GPx) activity level creatinine, lactate, hydrogen peroxide, reduced estimated clinical diagnostic kits. A pronounced upward trend creatinine content, CPK LDH increasing degree alcoholic myopathy during detected. Administration C60FAS shown to reduce biochemical injury oxidative processes by maintaining balance between pro-oxidant antioxidant systems. The maximum positive effect observed when I). results indicate on C60 ability correct pathological condition muscular system arising from intoxication. Keywords: intoxication, system, fullerene, creatine phosphokinase, muscle,